Abstract
Three-week- and three-month-old female rats were injected intraperitoneally once with 42 mg boron (as sodium borate)/kg. The distribution of boron in selected tissues was investigated at different time intervals after injection. The highest amounts of boron were found in the kidney, liver, heart, and blood, 30 min after injection, but rapidly returned to control level four hr later. Boron level in the brain was relatively low but remained fairly constant throughout the experiment. Also, threeweek old rats received 100 ppm boron in their drinking water for 21 days. Boron levels in kidney, liver, and brain increased steadily during the first nine days of treatment, but returned to the control levels, although blood boron concentration continued to rise up to day 21. Boron, either i.p. injected or ingested orally significantly potentiated ethanol and hexobarbital induced sleep.
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