Abstract
Upregulation of GADD45a, TP53 and CASP3 mRNA Expression in the Rat Lens after In vivo Exposure to Sub-threshold Dose of UVR B
Highlights
IntroductionExperimental [2,3,4] and epidemiological [5,6,7] studies associate exposure to UVR-B and cortical cataract
Age-related cataract is the leading cause of blindness in the world [1]
Results mRNA expression of the GADD45α gene mRNA expression of the genome stress sensor GADD45α gene is increased at 1 h after UVR exposure as evaluated from a 95%
Summary
Experimental [2,3,4] and epidemiological [5,6,7] studies associate exposure to UVR-B and cortical cataract. A cross-sectional Chesapeake Bay study of 838 watermen found a link between the degree of solar UVR-B exposure and human cortical cataract [8]. Subjects with cortical cataract had a 21% higher average annual exposure to UVR-B from the age of 16, indicating that damage to the lens is cumulative. A recent experimental study in rats concluded that repeated daily in vivo sub-threshold exposures to UVR-B for 30 days partly cumulate and cause cataract in rats [9]. Transmission electron microscopy studies showed UVR-B induced apoptosis in the lens in vivo [12,13].
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