Abstract
Treatment of Staphylococcus Aureus with Antibiotic and Quorum-Sensing Inhibitor Combinations Reduces Severity of Keratitis
Highlights
Staphylococcus is a leading cause of bacterial keratitis in humans [1]
The pathology associated with S. aureus keratitis might be produced by release of microbial toxins, not by replication of bacteria in the cornea [6,7]
The fimbrolide at the sub-minimum inhibitory concentration (MIC) of concentration had no effect of bacterial growth
Summary
Staphylococcus is a leading cause of bacterial keratitis in humans [1]. Bacterial keratitis is a major cause of ocular morbidity and avoidable visual impairment worldwide with concomitant potential for increased social and health care costs [2,3]. The pathology associated with S. aureus keratitis might be produced by release of microbial toxins, not by replication of bacteria in the cornea [6,7]. A number of S. aureus virulence factors have been implicated in the pathogenesis of corneal disease. These include factors such as α-toxin and β-toxin both of which are membrane active toxins that permeabilize mammalian cell membranes leading to cell death [6,7,8]. The production of α toxin and β-toxin is controlled at least in part, by the staphylococcal accessory gene regulator (agr) quorum-sensing system [9]
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