Abstract
Two and a half years ago, World Psychiatry published a Forum about the US National Institute of Mental Health (NIMH) Research Domain Criteria (RDoC) initiative1. In it, there was spirited commentary with divergent views of diagnosis and critical examination of RDoC. Some criticisms were based on an incomplete understanding of RDoC2, but the discussion captured the challenge of shifting the paradigm for psychiatric nosology. Here I provide an update on RDoC, while articulating some fundamental issues.
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