Abstract
Resveratrol oligomers (REVs), a major class of stilbenoids, are biosynthesized by regioselective oxidative coupling of two to eight units of resveratrol monomer. Due to their unique structures and pleiotropic biological activities, natural product chemists are increasingly focusing on REVs in the last few decades. This study presents a detailed and thorough examination of REVs, including chemical structures, natural resources, and biological activities, during the period of 2010–2017. Ninety-two new REVs compounds, including 39 dimers, 23 trimers, 13 tetramers, six resveratrol monomers, six hexamers, four pentamers, and one octamer, have been reported from the families of Dipterocarpaceae, Paeoniaceae, Vitaceae, Leguminosae, Gnetaceae, Cyperaceae, Polygonaceae Gramineae, and Poaceae. Amongst these families, Dipterocarpaceae, with 50 REVs, accounts for the majority, and seven genera of Dipterocarpaceae are involved, including Vatica, Vateria, Shorea, Hopea, Neobalanocarpus, Dipterocarpus, and Dryobalanops. These REVs have shown a wide range of bioactivities. Pharmacological studies have mainly focused on potential efficacy on tumors, bacteria, Alzheimer’s disease, cardiovascular diseases, and others. The information updated in this review might assist further research and development of novel REVs as potential therapeutic agents.
Highlights
Resveratrol oligomers (REVs), a major class of stilbenoids, are commonly biosynthesized by regioselective oxidative coupling of two to eight units of resveratrol monomer [1]
REVs were mainly found in nine plant families
REVs have been found in seven additional plant families
Summary
Resveratrol oligomers (REVs), a major class of stilbenoids, are commonly biosynthesized by regioselective oxidative coupling of two to eight units of resveratrol monomer [1]. 92 new REVs were isolated and identified, provides a detailed and thorough examination of their chemical structures, natural resources, and and including 39 dimers, 23 trimers, 13 tetramers, six resveratrol monomers, six hexamers, four pentamers, biological activities, from to. In this period, new REVs were isolated and identified, one octamer. These REVs are mostly distributed including 39 dimers, 23 trimers, 13 tetramers, six resveratrol monomers, six hexamers, four pentamers, in the following seven families: Dipterocarpaceae, Paeoniaceae, Vitaceae, Leguminosae, Gnetaceae, and one octamer.
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