Oxidants and antioxidants in metabolic syndrome and cancer.

Si Jin,Xiao Qian Chen,Shiwei Deng,Yongzhong Wu,Jinxiang Zhang

doi:10.1155/2014/178962

Abstract

Oxidants and antioxidants in metabolic syndrome and cancer.

Highlights

Insulin is critically involved in metabolism regulation and closely associates with both diabetes and cancer, the precise molecular mechanism is not fully elucidated
Whereas a recent hypothesis paper by Watson, the famous Nobel Prize winner, suggests that diabetes, dementias, cardiovascular disease, and some cancers may be linked to a failure to generate sufficient reactive oxygen species (ROS) [6], which maybe reflects the situations in end stages of these complex diseases
Li et al conducted an interesting study, which demonstrates that insulin increases pyruvate kinase M2 (PKM2) expression through ROS for the regulation of glucose consumption and lactate production “Insulin regulates glucose consumption and lactate production through reactive oxygen species and pyruvate kinase M2”

Summary

Introduction

Insulin is critically involved in metabolism regulation and closely associates with both diabetes and cancer, the precise molecular mechanism is not fully elucidated. Whereas a recent hypothesis paper by Watson, the famous Nobel Prize winner, suggests that diabetes, dementias, cardiovascular disease, and some cancers may be linked to a failure to generate sufficient reactive oxygen species (ROS) [6], which maybe reflects the situations in end stages of these complex diseases.

Results

Conclusion