Abstract
Introduction: Multiple sclerosis (MS) is an au toimmune demydinating disease of the cemral nervous system the aetiology of which remains so far unknown and which probably mvolves: .genetic, immune,_ inflammatory, as well as environmental factors. OBJECTIVES: A review of the current and past ltterature on multiple sclerosis to provide a concise and comprehensive educational resource mainly for postgraduate medica l students, but a lso for undergrad. uate med ical colleges students as well as other medical practioners and their patients. The aim being to present a simplified and clinically relevant summary of the main man ifestations, an_d ma~agement ofmulti~le sclerosis, with an update on cu rrent theories of pathophysiology, aetiology: a nd the basis behind the therapeutic agents used in current clinical practice. METHODS: The standard medical texts and journals relating lo MS were consulted as well as reliance on own experience of patients attending the teaching hospitals, and clinics in Benghazi Libya with a diagnosis of multiple sclerosis. Local a nd worldwide epidemiological published data were also reviewed. RESULTS: The incidence of multiple sclerosis varies worldwide. Eastern Libya is an area of high risk MS incidence. The impor tance is emerging of a genetic role in the already known immune pathogenesis of multiple sclerosis. Diet and light have regained importance in the aetiology of the disease. Investigations are advancing and help to differentiate the 
 disease from other mimicking conditions. Biomarkers help to define diagnosis and determine prognosis. CONCLU SIONS: Multiple sclerosis is an important neurological disease with protean CNS manifestations which must be con sidered in the differential diagnosis of neurological symptoms at all ages: although commonly considered a disease of young people, especially females. A countrywide database may help to collate efforts and resources, as well as unify data regarding the number and presentation of patients, to assess their requirements.
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