Abstract
Up Close and Personal with an Internal-Membrane Virus
Highlights
Viruses have evolved a multitude of strategies for infiltrating their genome into host cells
Enveloped viruses such as herpesvirus and poxviruses wrap their genetic payload within a protein shell, or capsid, which itself is swathed in a lipid membrane that can fuse with a target cell’s outer membrane
Other viruses, such as tailed bacteriophages, use a more complex mechanism: they inject their DNA into a host cell through a rigid tail that extends from their capsid
Summary
Viruses have evolved a multitude of strategies for infiltrating their genome into host cells. Enveloped viruses such as herpesvirus and poxviruses wrap their genetic payload within a protein shell, or capsid, which itself is swathed in a lipid membrane that can fuse with a target cell’s outer membrane. Other viruses, such as tailed bacteriophages, use a more complex mechanism: they inject their DNA into a host cell through a rigid tail that extends from their capsid.
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