Abstract
The genital tubercle (GT), an anlage of the external genitalia, differentiates into a penis in males and a clitoris in females. From 12.5 days postcoitum (d.p.c.), the embryo GT development show a sexually dimorphic difference between the male and the female, and its initiation and maintenance are androgen-dependent processes. Studies concerning the role of androgens in this period have documented a requirement of 3 factors, that is 1) production of T by the fetal testes, 2) conversion of T to DHT via the enzyme 5α-reductase type 2 and 3) a functional AR. GT development concerned a series of basic morphological processes, i.e., luminization, fusion, or merging, followed by definitive differentiation, that are used to describe the embryogenesis of certain other structures such as the nasal cavity, palate, nasolacrimal duct. Very complicated signaling concerned and its interaction between the epithelium and mesenchyme is bidirectional.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
