Unveiling Therapeutic Prospects: Evaluating the Anti-Arthritic Properties of Thymosin Alpha 1

Abstract

Background: Thymosin alpha 1 is a peptide naturally occurring in the thymus that has long been recognized for modifying, enhancing, and restoring immune function. Purpose: The present study focuses on the effects of Thymosin alpha 1 on Body weight, Paw weight, paw volume and arthritic score of Collagen induced arthritis (CIA) rats. Methods: The wistar rats were randomly divided into 5 groups: nor-mal control, arthritic control, CIA+Ta-1 0.25mg/kg, CIA+Ta-1 0.5mg/kg and CIA+Ta-1 mg/kg. The collagen and lipopolysaccharide (LPS) were administered via the intraplantar route to the experimental rat subjects. Prior to the administration of collagen and LPS, the initial paw volume was measured, and the body weight was duly document-ed. The administration of the treatment occurred on the first, third, and fifth days. On the completion of the dosing period, specifically on the fifteenth day, the final body weight was duly recorded. The measurements of paw volume, paw weight, Body weight and arthritic score were duly recorded. Results: Following with the administration of Thymosin alpha-1 the arthritic rats shown significantly reduce the severity of arthritis by decreasing the symptoms of arthritis. Conclusions: Thymosin alpha-1 has shown a promising effect of the reduction in the pathophysiology of rheumatoid arthritis and hence it can be a better therapeutic candidate of future for the management of RA. The more detailed analysis of the mechanistic study may provide a better understanding.