"Unveiling Onychomycosis: Pathogenesis, Diagnosis, and Innovative Treatment Strategies"

Abstract

Onychomycosis, a widespread fungal nail infection, manifests as discoloration, thickening, and detachment of nails, often affecting the surrounding skin. While dermatophytes were historically considered the primary causative agents, recent studies reveal a rise in non-dermatophyte mold (NDM) infections, particularly in warmer climates. Dermatophytes dominate toenail infections, while yeasts and molds also contribute to fingernail infections, with certain molds like Fusarium spp. and Scytalidium spp being notable culprits. Diagnostic challenges arise from elevated false-negative rates in conventional methods like microscopy and culture, particularly with NDM infections. Histology and polymerase chain reaction (PCR) offers higher accuracy, albeit requiring multiple confirmations due to contamination risks. Treatment options encompass oral antifungals with higher cure rates but significant side effects and topical treatments with milder side effects but inferior efficacy. Several ongoing research aims to enhance transungual delivery through various approaches for the treatment of onychomycosis. Recurrence rates underscore the importance of prompt treatment, footwear hygiene, and preventive measures like topical treatments to mitigate the risk of reinfection. Understanding the evolving fungal landscape in onychomycosis is critical for effective management and recurrence prevention strategies.