Abstract
Positive correlation between gene expression and synonymous codon usage bias is well documented in the literature. However, in the present study of Vibrio cholerae genome, we have identified a group of genes having unusually high codon usage bias despite being low potential expressivity. Our results suggest that codon usage in lowly expressed genes might also be selected on to preferably use non-optimal codons to maintain a low cellular concentration of the proteins that they encode. This would predict that lowly expressed genes are also biased in codon usage, but in a way that is opposite to the bias of highly expressed genes.
Highlights
In most species synonymous codons are not used with possibilities, earlier unavailable, have opened up to equal frequencies; the phenomenon known as codon usage understand the genetic organization of Vibrio cholerae.bias
Our results clearly suggest that presence of non-optimal codons has been postulated to translational selection has significant influence on the reduce translation rate [10], probably due to a relative codon usage pattern of lowly expressed genes depending scarcity of cognate tRNA species
Results and Discussion: axis is significantly correlated with the corresponding Codon Adaptation Index (CAI)
Summary
Synonymous codon usage pattern of lowly expressed genes Saccharomyces cerevisiae, synonymous codon usage bias expectation, we have identified 138 genes that are highly has been shown to be correlated with the abundance of biased yet lowly expressed. Our results clearly suggest that presence of non-optimal codons has been postulated to translational selection has significant influence on the reduce translation rate [10], probably due to a relative codon usage pattern of lowly expressed genes depending scarcity of cognate tRNA species.
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