Unusual Association: Dermatomyositis Diagnosis Tied to Rare Presence of TPO Autoantibodies

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The co-occurrence of autoimmune diseases is prevalent and largely documented. However, the simultaneous presence of dermatomyositis and autoimmune thyroid disorders remains comparably uncommon, despite both being autoimmune in nature. In this report, we present a case of a 60-year-old Bangladeshi American individual delineating clinical manifestations consistent with dermatomyositis, including Gottron's papules, the V-sign, Shawl sign, and skin abnormalities, noticeably hypopigmented areas on the scalp and face. Although muscle biopsy results in this patient did not align strictly with classical dermatomyositis, they illustrated a combination of necrotizing myopathy and dermatomyositis. Notably, laboratory findings conceded the presence of TPO autoantibodies, despite the absence of clinical signs or symptoms of hypothyroidism. This discovery recommends the possibility of an underlying autoimmune thyroid condition. Our case prompts consideration of whether a distinct subtype of dermatomyositis may be associated with autoimmune thyroid conditions, even in the absence of overt thyroid manifestations.