Abstract
Methods Five patients with CHD were included in this pilot study (table 2 in Figure 2). The FB MR studies were performed on a Philips Acheiva 1.5T magnet using a 5-channel phased array coil (see Table 1 in Figure 1) 1. Respiratory synchronized [1], time-resolved MRA 2. Equilibrium phase MRA 3. 3D cine SSFP 4.4D phase contrast (PC) flow imaging 5.3D whole-heart single phase SSFP (coronary) Comparative data was obtained using conventional 2D cine RT SSFP sequences [2] in the VLA, 4 chamber and short axis planes, and 2D PC imaging. Data Analysis: Image quality assessment and quantitative volumetric and flow analysis were performed by three blinded, experienced users. MRA images were graded using a semi-quantitative scale from 1-5 for relevant imaging targets in CHD [1], with 1: excellent, no limitations, and 5: non-diagnostic. The clinical scoring system for 2D and 3D cine SSFP was based on bloodmyocardial contrast, endocardial edge definition and inter-slice alignment [2]. Paired t-test analysis was performed on LV and RV volumes obtained by an experienced observer using the same software
Highlights
Cardiac MRI for congenital heart disease (CHD) is an operator dependent and time-intensive examination requiring real-time decision making regarding choice of sequences, planes, and acquisition parameters to adapt to unique morphological and functional variables in a given patient.relevant imaging targets in CHD [1], with 1: excellent, no limitations, and 5: non-diagnostic
Equilibrium phase MRA 3. 3D cine SSFP 4.4D phase contrast (PC) flow imaging 5.3D whole-heart single phase SSFP Comparative data was obtained using conventional 2D cine RT SSFP sequences [2] in the VLA, 4 chamber and short axis planes, and 2D PC imaging
Clinical scores for 2D SSFP were consistently better than 3D-SSFP, but 3D SSFP images were adequate for recognition of pathology in all cases (2D vs 3D: 1.5 ± 0.5 vs 1.6 ± 0.9) and had better inter-slice alignment (1.4 ± 0.5 vs 1 ± 0)
Summary
Cardiac MRI for congenital heart disease (CHD) is an operator dependent and time-intensive examination requiring real-time decision making regarding choice of sequences, planes, and acquisition parameters to adapt to unique morphological and functional variables in a given patient. Relevant imaging targets in CHD [1], with 1: excellent, no limitations, and 5: non-diagnostic. The clinical scoring system for 2D and 3D cine SSFP was based on bloodmyocardial contrast, endocardial edge definition and inter-slice alignment [2]. Paired t-test analysis was performed on LV and RV volumes obtained by an experienced observer using the same software
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