Abstract
To find out the mechanism of induction for delayed chromosome aberrations, mouse A9 cells containing a human chromosome 11 were irradiated with 6 or 15 Gy of X-rays, and then the human chromosome was transferred into unirradiated mouse m5S cells using a microcell-mediated chromosome transfer. Chromosome aberrations were analyzed by whole chromosome painting using a probe specific for human chromosome 11. In a microcell hybrid transferred with 15 Gy-irradiated chromosomes 11, all chromosomes 11 were fragmented and 45% of the chromosomes 11 were rearranged after chromosome transfer. Similarly, in a microcell hybrid transferred with 6 Gy-irradiated chromosome 11, 25% and 46% of the chromosomes 11 were rearranged to form rings and telomeric fusion chromosomes, respectively. These results suggest that the irradiated chromosome per se is of an unstable nature, and that telonomic instability induced by radiation is possibly involved in the induction of delayed chromosome aberrations.
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