Unstable Angina Associated with Factor VIII Concentrate Therapy for Hemophilia A

Abstract

Brief Report1 August 1986Unstable Angina Associated with Factor VIII Concentrate Therapy for Hemophilia AROBERT G. KOPITSKY, M.D., EDWARD M. GELTMAN, M.D.ROBERT G. KOPITSKY, M.D.Search for more papers by this author, EDWARD M. GELTMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-105-2-215 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe importance of intracoronary thrombosis in patients with atherosclerotic coronary stenosis has been well established in the pathogenesis of acute transmural myocardial infarction (1). Recent angiographic studies have shown that intracoronary thrombi also occur in many patients who have unstable angina without myocardial infarction (2-5). In patients with severe atherosclerotic coronary obstruction, it is conceivable that a severe coagulation defect could partially protect against unstable angina or acute myocardial infarction by impairing the ability to form intracoronary thrombi; correction of the defect could negate this protection. We describe a case of severe unstable angina associated with the use of factor...References1 DEWOODSPORESNOTSKE MJR. Prevalence of total coronary occlusion during the early hours of transmural myocardial infarction. N Engl J Med. 1980;303:897-902. CrossrefMedlineGoogle Scholar2. HOLMESHARTZLERSMITHFUSTER DGHV. Coronary artery thrombosis in patients with unstable angina. Br Heart J. 1981; 45:411-6. CrossrefMedlineGoogle Scholar3. VETROVECLEINBACHGOLDCOWLEY GRHM. Intracoronary thrombolysis in syndromes of unstable ischemia: angiographic and clinical results. Am Heart J. 1982;104(4 pt 2):946-52. CrossrefMedlineGoogle Scholar4. MANDELKORNWOLFSINGH JNS. Intracoronary thrombus in nontransmural myocardial infarction and in unstable angina pectoris. Am J Cardiol. 1983;52:1-6. CrossrefMedlineGoogle Scholar5. ZACKISCHINGERAKERDINCERKENNEDY PTUBH. The occurrence of angiographically detected intracoronary thrombus in patients with unstable angina pectoris. Am Heart J. 1984;108:1408-12. CrossrefMedlineGoogle Scholar6. BUJAWILLERSON LJ. Clinicopathologic correlates of acute ischemic heart disease syndromes. Am J Cardiol. 1981;47:343-56. CrossrefMedlineGoogle Scholar7. GALLINOHAEBERLIBAURSTRAUB AAHP. Fibrin formation and platelet aggregation in patients with severe coronary artery disease: relationship with the degree of myocardial ischemia. Circulation. 1985;72:27-30. CrossrefMedlineGoogle Scholar8. OLIVA P. Unstable rest angina with ST-segment depression: pathophysiologic considerations and therapeutic implications. Ann Intern Med. 1984;100:424-40. LinkGoogle Scholar9. FUERTHMAHRER JP. Myocardial infarction after factor IX therapy. JAMA. 1981;245:1455-6. CrossrefMedlineGoogle Scholar10. SULLIVANPURDYBILLINGHAMGLADER DLMB. Fatal myocardial infarction following therapy with prothrombin complex concentrates in a young man with hemophilia A. Pediatrics. 1984;74:279-81. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROBERT G. KOPITSKY, M.D.; EDWARD M. GELTMAN, M.D.Affiliations: Washington University School of Medicine St. Louis, Missouri PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byParadoxical thrombosis part 1: factor replacement therapy, inherited clotting factor deficiencies and prolonged APTTEndothelial dysfunction in haemophilia patientsClassic Polyarteritis Nodosa Presenting Rare Clinical Manifestations in a Patient with Hemophilia APotential role for rFVIIa in transfusion medicineAcute left anterior descending artery occlusion in a hemophiliac A patient during recombinant factor VIII infusion: Treatment with coronary angioplastySevere Haemophilia A Patient with Factor V Leiden Homozygosity Associated with Portal Vein Thrombosis and Myocardial InfarctionCerebral infarct associated with factor V Leiden mutation in a boy with hemophilia AFactor VIII, HIV and AIDS in haemophiliacs: an analysis of their relationshipAssociation of severe haemophilia A and factor V Leiden: report of three casesFatal complication of desmopressinFactor VIII, HIV and AIDS in haemophiliacs: An analysis of their relationshipDeep venous thrombosis in hemophilia A 1 August 1986Volume 105, Issue 2Page: 215-216KeywordsAcute myocardial infarctionCardiology and cardiovascular diseasesHemophilia AMyocardial infarctionPathogenesisStable coronary artery diseaseStenosisThrombosisUnstable angina ePublished: 1 December 2008 Issue Published: 1 August 1986 PDF downloadLoading ...