Abstract
AbstractWe report here on three oligopeptide amphiphiles (OPA1‐3) with different unsaturated double bonds, which self‐assemble into shape‐specific nanostructures. It was found that OPA1 with saturated hydrophobic tail self‐assembled into conventional cylindrical nanofibers, while the unsaturated OPA2‐3 molecules self‐organized into helical nanoarchitectures. Due to the different double bond numbers in hydrophobic tails of OPA2‐3, the helical pitch and width of their self‐assemblies varied. Specially, linoleic acid‐bearing OPA3 could be oxidized by lipoxidase to create hydroperoxide‐containing OPA4, which further generated singlet oxygen (1O2) in the presence of catalytic iron (II) ion. The established system may provide a self‐deliverable nanoplatform for 1O2‐mediated cancer treatment.
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