Abstract
Background and Aims: Chemokine receptors are important in perpetuating chronic vascular inflammation. Our published work (Van der Vorst et al., ATVB 2019) showed that hematopoietic deficiency of the chemokine like receptor ChemR23 increases the proportion of alternatively activated M2 macrophages and attenuates pDC recruitment to lymphatic organs and atherosclerotic lesions, in murine models. However, conflicting results in systemic ChemR23-deficient animals (Laguna-Fernandez et al., Circulation 2018) suggests ChemR23 has a diverse role within atherosclerosis. Therefore, we investigated the role of ChemR23 on arterial endothelial and smooth muscle cells.
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