Abstract
Sodium taurocholate co-transporting polypeptide (NTCP) is encoded by the solute carrier family 10 member 1 (SLC10A1) gene and is predominantly expressed on the sinusoidal membrane of hepatocytes with the function of hepatic uptake of bile salt, steroid hormones, thyroid hormones, and various bile-acid-conjugated drugs. Almost 10 years ago, NTCP was identified as a functional cellular entry receptor of hepatitis B and hepatitis D viruses (HBV/HDV, respectively),1 which are among the major etiological factors leading to cirrhosis, liver failure, and hepatocellular carcinoma and affect around 250 million people worldwide.
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