Abstract
The current study presents a direct CF2H radical addition to C[double bond, length as m-dash]N bonds predicated on the photocatalytic activation of commercially available zinc difluoromethanesulfinate. The mild conditions in place lead to impressive structural diversity, as quinoxalinones and dibenzazepines, among others, are successfully functionalized.
Highlights
The current study presents a direct CF2H radical addition to CQN bonds predicated on the photocatalytic activation of commercially available zinc difluoromethanesulfinate
The mild conditions in place lead to impressive structural diversity, as quinoxalinones and dibenzazepines, among others, are successfully functionalized
Fluorine stands as the most abundant halogen on Earth, yet it has played an insignificant role during the natural biosynthesis of organic molecules.[1]
Summary
The current study presents a direct CF2H radical addition to CQN bonds predicated on the photocatalytic activation of commercially available zinc difluoromethanesulfinate. The mild conditions in place lead to impressive structural diversity, as quinoxalinones and dibenzazepines, among others, are successfully functionalized.
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