Direct Acyl Radical Addition to 2H-Indazoles Using Ag-Catalyzed Decarboxylative Cross-Coupling of α-Keto Acids

Abstract

A direct acyl radical addition to 2 H-indazoles has been achieved for the first time, where the less-aromatic quinonoid 2 H-indazoles readily accepted radical species to the C-3 position. Motivated by the lack of direct acylation strategy for 2 H-indazoles, the current method utilizes the radical acceptability of 2 H-indazoles, discovering an ambient temperature reaction to provide facile access to a diverse array of 3-acyl-2 H-indazoles with three points of structural diversification in 25%-83% yields.