Unique Crystal Structure of a Self-Assembled Dinuclear Cu Peptoid Reveals an Unusually Long Cu···Cu Distance.

Abstract

Studies on a series of molecular dicopper peptoid complexes showed that the Cu···Cu distances measured in X-ray single-crystal diffraction are typically in the range of 4.2-6.9 Å. Herein, we designed a new peptoid, L1, having 2,2'-bipyridine, propyl, and pyridyl side chains and discovered that although it forms a typical dicopper self-assembled structure (complex 1), the Cu···Cu distance is exceedingly long -8.043 Å. By analyzing its structure and surface properties in comparison to a control Cu-peptoid complex (2), in which the pyridyl side chain is modified by an ethanolic side chain, we suggest that the long Cu···Cu distance is contributed by the hydrophilic-hydrophobic interaction influenced by the pyridyl side chain and the steric hindrance of the propyl side chain. This result may motivate the use of dinuclear Cu peptoid complexes for wider applications, such as cooperative catalysis and luminescence.