Abstract
Optimal conditions are found for the simultaneous determination of tranexamic acid, ampasse, and ethylmethylhydroxypyridine succinate by reversed-phase HPLC. As is shown, under these conditions the reversed-phase mechanism of retention prevails and the analytes occur mainly in a specific ionic state with an optimal retention time. The possibility of using chromatography columns from various manufacturers is estimated. The method was used to analyze title materials and impurities in drug formulations.
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