Abstract
Schiff bases and benzimidazoles compounds exhibit an extensive range of therapeutic applications, such as anticancer agents. The present study shows the synthesis of the 2-(4-methoxyphenyl)-1H-benzimidazole hydrochloride (BenzHCl) from N,N’-bis-(4-methoxybenzylidene)-benzene-1,2-diamine (Anisalophen) mediated by chloride lanthanide (Gd3+, Tb3+, or Eu3+). The mechanism of the reaction is proposed from different synthetic strategies. BenzHCl crystallizes in the monoclinic system, space group P21 and shows the iminic nitrogen atom protonated, which is stabilized by the chlorine ion. BenzHCl and Anisalophen were characterized, and their thermal stabilities were analyzed by TG/DTA techniques. Anisalophen and BenzHCl showed higher cytotoxic activity against human breast cancer cells (MCF-7 and MDA-MB-231) when compared to human fibroblast cells.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
