Abstract
The CHA2DS2-VASc stroke risk score has been recommended by the European Society of Cardiology atrial fibrillation (AF) guidelines to guide decision on oral anticoagulation (OAC) prescription in AF patients. Although female sex initially was considered an individual risk factor warranting antithrombotic treatment in all female AF patients independent of other risk factors, this recommendation was revised as growing evidence showed that, rather, female sex is a risk modifier, as sex does not contribute to stroke risk in the absence of other risk factors.
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