Abstract
During myogenesis, mononucleated proliferating cells undergo cell to cell fusion to form multinucleated myotubes and finally striated skeletal muscle. Does membrane tension need to be regulated to achieve proper fusion during initial stages of fusion and how? Does it need to be changed for the whole cell or only locally? We use interference reflection microscopy to answer some of these questions using C2C12 cells which are tracked at the single cell level through 5 days of differentiation. We find that a global increase in tension is the outcome of differentiation while an interim drop in tension and spatial heterogeneities may facilitate the initial stages.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
