Abstract
Abstract Tuberculosis (TB) remains a significant global health concern, with a quarter of the world's population infected. Understanding the immune response against Mycobacterium tuberculosis (Mtb) is crucial for developing effective strategies to control TB. Previous work from various groups, including our lab, has indicated that the induction of IL-17 plays a protective role during Mtb disease progression. However, the downstream cells that sense and respond to IL-17 and how they shape the induction of protective immune responses remain unclear. The current study focuses on understanding the role of IL-17RA-mediated signaling in regulating the immune response against Mtb infection. The study aims to investigate the role of IL-17 signaling in specific innate myeloid immune cell populations and its effect on TB disease progression. Using Cre-Flox based conditional knockout mice lacking IL-17RA, we explored the role of IL-17 signaling in different cellular components of myeloid immune cells, regulating disease progression and initiating the immune response. Our work elucidated the involvement of LysM-expressing cells as the primary responder to IL-17RA-mediated signaling in regulating the protective immune response against TB during the early stages of infection. By understanding the role of IL-17 signaling in the immune response against Mtb, this study aims to provide insights into potential strategies for controlling TB and improving vaccine design.
Published Version
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