Understanding Prostate Cancer Cells Metabolome: A Spectroscopic Approach

Francisco Santos,Isabel Valença,Sandra Magalhães,Daniela Ribeiro,Beatriz Silva,Magda Carvalho Henriques,Margarida Fardilha,Alexandra Nunes

doi:10.2174/2213235x07666181122124106

Abstract

Understanding Prostate Cancer Cells Metabolome: A Spectroscopic Approach

Highlights

Worldwide, 1.1 million new cases of Prostate cancer (PCa) were registered in 2012, 307,000 of which resulted in death
PNT2 cell line was kindly given by Dr Ricardo Perez-Tomás (University of Barcelona, Spain). 22Rv1 and PNT1A were a kind gift from Dr Fátima Baltazar (University of Minho, Portugal)
3.1 Overview of Fourier-transform infrared (FTIR) spectra Cell viability was confirmed by observation under the microscope, and each cell pellet consisted of mostly viable cells

Summary

Introduction

1.1 million new cases of PCa were registered in 2012, 307,000 of which resulted in death. These figures place PCa as the second most common oncological disease in men, ranking just behind lung cancer [1]. Many risk factors have been associated with PCa, such as race, family history and increasing age, with more than 60% of new cases being diagnosed in men aged between 60 and 70 years [1,2]. Despite being one of the most used, PSA testing is unspecific and false positive results are common, due to non-cancerous diseases such as benign prostatic hyperplasia [3]. The 5-year survival rates are very optimistic (up to 100%) for patients diagnosed at an early stage, it declines to approximately 28% for patients diagnosed with late-stage cancer, so there is a need for new and effective therapeutic strategies [5]

Objectives

Methods

Results

Conclusion