Understanding corneal permeation of lincosamide antimicrobials: in-vitro studies with synthetic stromal models

Abstract

Purpose: Lincomycin and clindamycin are structurally related antimicrobials useful for treatment of both Gram- positive and Gram-negative anaerobes. On topical application therapeutic levels are attained in the cornea, aqueous humor, and iris-ciliary body, but despite structural similarity, behavioural differences occur. Clindamycin has higher overall concentration and shorter peak onset values in ocular tissues. This poster describes the use of in-vitro permeation through a corneal stromal model in the study of these behavioural differences.