Underlying Ehlers-Danlos syndrome discovered during neuro-ophthalmic evaluation of concussion patients: a case series

Abhishek Gami,Eric L Singman

doi:10.1186/s12886-019-1174-2

Abstract

BackgroundThe Ehlers-Danlos syndromes are a heterogenous group of diseases that cause connective tissue defects. At present, there are no published reports focusing upon the neuro-ophthalmic symptoms that might occur in EDS patients after mild traumatic brain injury. The demographics and clinical course of seven patients with subclinical EDS and mild traumatic brain injury are presented.Case presentationThis series describes patients with Ehlers Danlos Syndrome whose diagnosis was discovered in a neuro-ophthalmic clinic for brain injury. Patient demographics and neuro-ophthalmological symptoms are presented.ConclusionsPatients with subclinical EDS and brain injury may experience a slower, less complete recovery course. Heightened awareness of undiagnosed or underlying Ehlers Danlos Syndrome is important for patients and providers.

Highlights

The Ehlers-Danlos syndromes are a heterogenous group of diseases that cause connective tissue defects
In the following case series, we report neuro-ophthalmic manifestations that developed in patients with underlying Ehlers-Danlos Syndrome (EDS) or joint hypermobility disorders following traumatic brain injury (TBI)
Patient 4 Patient 4 is a 49-year-old woman who first presented to the Wilmer Traumatic Brain Injury Clinic (W-TBI) clinic in February 2017 after experiencing new ophthalmic symptoms following a concussion from hitting her head on a metal beam

Summary

Introduction

The Ehlers-Danlos syndromes are a heterogenous group of diseases that cause connective tissue defects. Patient 1 returned to the clinic in October 2017 and reported that she had to discontinue her home orthoptic exercises because they continued to cause headaches and nausea.

Results

Conclusion