Abstract
FOLLOWING on the heels of the massive Human Genome Project, which revealed the sequence of the human genome, a huge consortium of scientists has unveiled its preliminary progress in rigorously analyzing various stretches of that genetic blueprint ( Nature 2007, 447, 799 and entire issue of Genome Res. 2007, 17). Participants in the ENCODE (Encyclopedia of DNA Elements) project devised and tested a wide variety of high-throughput experimental and computational methods for identifying functional elements in a representative fraction of the genome. Such functional elements include sequences that code for proteins, sequences that don't code for proteins, regulatory sequences that control the transcription of DNA, and sequences that control the packaging of the genome. The consortium's effort has revealed quite a few surprises about the genomic landscape. For instance, the team reports that the majority of DNA-whether it encodes proteins or not-is transcribed into RNA. This ...
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