Abstract
ENCODE and its first impractical application
Highlights
The C value paradox, as initially coined, was encountered in early eukaryotic genomic studies with the oddity that genome size was not necessarily correlated with organism complexity [1]
The most exciting finding and one that may begin to address the two questions posed above was that 80.4% of the genome has a biochemical function, that is, it is covered by or near at least one Encyclopedia of DNA Elements (ENCODE)-identified element
The authors state that “95% of the genome lies within 8 kilobases of a DNA–protein interaction. . ., and 99% is within 1.7 kb of at least one of the biochemical events measured by ENCODE.”
Summary
The C value paradox, as initially coined, was encountered in early eukaryotic genomic studies with the oddity that genome size was not necessarily correlated with organism complexity [1]. The most exciting finding and one that may begin to address the two questions posed above was that 80.4% of the genome has a biochemical function, that is, it is covered by or near at least one ENCODE-identified element.
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