Abstract
Various high-to-low dose extrapolation models (Probit, Logit, Extreme-Value, One-Hit, Multistage) are applied to all 6 available data sets (Kociba et al. study, 1978: male and female Sprague-Dawley rats; National Toxicology Program study, 1982: male and female Osborne-Mendel rats, male and female B6C3F1 mice), in order to assess 2,3,7,8 TCDD-related carcinogenic risk at low doses. Our results show that risk assessment at low doses, based on experimental data, is limited by a huge amount of uncertainty (10 6 at least), according to both models and species under consideration.
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