Abstract
Colcemid, a derivative of colchicine, is well known for its capacity to inhibit microtubule formation in plant and animal cells. To determine the role of various microtubular systems such as the manchette, centrioles, and flagellar apparatus in mammalian spermiogenesis, adult male Chinese hamsters were injected daily with Colcemid at concentrations of from 6.5 x 10-5 M to 2.8 x 10-2 M. At various times following injections, the animals were sacrificed and testes and epidiymides were prepared for both light and electron microscopy.Concentrations greater than 2.7 x 10-4 M generally were lethal to animals within a period of 24 hours to 9 days. At lesser concentrations, animals survived normally without apparent ill effects.
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