Abstract
Sertoli-Leydig cell tumors of the ovary are comparatively rare, comprising less than 0.1% of ovarian neoplasms. It has been generally accepted that they are derived from remnants of primitive male directed cells of the indifferent stage of gonadal development. However, another postulate is that they originate from specialized ovarian stromal cells through different stages of differentiation. At the gross level, they tend to be nodular and solid with only focal evidence of cystic change. The histopathologic features vary with the degree of differentiation, ranging from tumors with well differentiated tubular structures lined by Sertoli cells with intertubular Leydig cells (Type I) to an undifferentiated sarcomatoid pattern (Type III) consisting of spindle shaped cells.
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Schedule a callMore From: Proceedings, annual meeting, Electron Microscopy Society of America
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