Abstract

 
 
 The goal of the study was to study the morphofunctional properties of ultrastructural changes in the cellular and extracellular structures of the adrenal glands during hypobaric hypoxia. The materials of the study were 30 male white rats weighing 180-200 grams. Thus, the results of the conducted studies showed that morphofunctional changes under the effects of acute hypoxia, which develop in different zones of the adrenal cortex, also change the histofunctional state of the adrenal medulla. Morphometric indicators of the adrenal parenchyma increase from the 5th day of hypoxia and are characterized by the increased blood supply to the adrenal glands, which occurs both by the dilatation of capillaries and by an increase in their density.
 
 
Highlights
Hypoxia or oxygen deficiency is a typical pathological process that occurs when the oxygen supply of tissues or its use in biological oxidation processes in the body is disrupted [1]
Chronic hypoxia or short-term effects of hypoxia are widely used in increasing the possibility of adaptation of the organism, psychophysiological states, respiratory system, cardiovascular system, mainly in the function of organs of the endocrine system, as well as in the treatment of many diseases and pathological processes [5,6]
In rats included in the control group, the adrenal glands are clearly visible on the upper poles of the kidneys in the retroperitoneal tissue space, under the diaphragm
Summary
Hypoxia or oxygen deficiency is a typical pathological process that occurs when the oxygen supply of tissues or its use in biological oxidation processes in the body is disrupted [1]. A person constantly feels the effect of oxygen deficiency or physiological hypoxia in his daily life. Changes in organs and tissues during physiologic hypoxia are of a short-term and reversible [2,3]. Chronic hypoxia or short-term effects of hypoxia are widely used in increasing the possibility of adaptation of the organism, psychophysiological states, respiratory system, cardiovascular system, mainly in the function of organs of the endocrine system, as well as in the treatment of many diseases and pathological processes [5,6]
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