Abstract
<h2>Abstract</h2> <ul><li>1.(1) Eight rabbits were fed a normal diet and placed in exposure chambers. Four were exposed to 0.018 vol. % carbon monoxide for 2 weeks, while the other 4 served as controls and were exposed to atmospheric air. At the end of the study tissue from arch and thoracic aorta was taken for transmission and scanning electron microscopy.</li><li>2.(2) The luminal aortic coats of the experimental animals showed pronounced changes, characterized first of all by a severe edematous reaction with extensive swelling, formation of subendothelial blisters, and plaque formation. Furthermore, the myointimal cells showed vacuolation and occasionally the endothelial cells showed severe degeneration with cytolysis and condensation. Apart from actual plaque formation, the surface structures were markedly swollen and irregular. Occasionally spotty or streaky lesions occurred, where the normal folding architecture had changed into a characteristic "cobblestone-like" picture formed by protruding, grossly edematous endothelial cells.</li><li>3.(3) The results support earlier findings of toxic effects of low concentrations of carboxyhaemoglobin on the arterial walls, thereby provoking increased endothelial permeability and formation of edema, leading to changes indistinguishable from early atherosclerosis.</li></ul>
Published Version
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