Abstract
The origin and pathogenesis of histiocytosis X disease still remain unclear. Neoplastic proliferation of histiocytes must be distinguished from the accumulation of histiocytes cells in response to an ”appropriate” stimulus, The cellular nature of proliferating histiocytes has been thought to be derived from Langerhans cells, because they share similar morphologic features and immunological expressions. Two cases of oral histiocytosis X (eosinophilic granuloma, Letterer-Siwe disease) were studied with light, electron microscopic and immunohistochemical techniques. Sections showed tumor cells were positively stained for S-100 protein. The ultrastructural studies of the tumor cells showed trilaminar or tennis racket shaped cytoplasmic organelles which could not be distinguished from those in the epidermal Langerhans cells. These results suggest that the origin of cells in histiocytosis X is probably the Langerhans cell or its precursor. Our findings would also support, at least partially, that histiocytosis X may be fundamentally an abnormal proliferation of Langerhans cells.
Published Version
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