Abstract
Beta-alanyl-melphalan (BAM) was demonstrated to have significant cancerocidal activity using both in vitro cultures and in vivo chemotherapy assays. Ultrastructural observations in the present study confirmed the antitumor activity of melphalan (MEL) and BAM. Results showed that the MEL affected the cellular elements causing marked cell damage both in mouse Ehrlich ascites tumor cells (MEATC) and mouse liver cells (MLC). BAM appeared to affect the cellular elements, with marked cell damage, only in MEATC, but not in the MLC. There were nuclear and cytoplasmic alterations in MEL and BAM treated MEATC, i.e. peripheral thickening of chromatin in nuclei, severe mitochondrial alterations, ribosome accumulation and autolysis phenomena which lead to the destruction of the subcellular structures.
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