Abstract
The epithelia of the gastric body and fundus are comprised of gastric pits (foveolae) and fundic glands. The transitional portion between the pit and the gland, corresponding to the isthmus and neck region, is the generative cell zone (1,2), where mitosis takes place. Most cells generated there migrate upwards along the gastric pit to the surface of the stomach to become surface mucous cells and are finally disposed of into the gastric lumen; whereas a few cells in the generative zone move downwards to differentiate into mucous neck cells, parietal cells, and chief cells, and eventually cell death occurs at the base of the gland, though their turnover is much slower than that of surface mucous cells.
Published Version
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