Abstract
Isolated turkey papillary muscles were acutely exposed to 0 or 6 µg/mL of cyclopiazonic acid (CPA) mycotoxin. Seven parameters of in vitro papillary muscle performance were significantly decreased. The performance criteria were maximum weight a muscle could lift (Po), work, maximum contraction and relaxation velocity, and times to initiation, peak, and completion of contractions. Calcium and adenosine triphosphate (ATP) availability appear to be responsible, in part, for these altered performances. Electron photomicrographs demonstrated that CPA-exposed muscles had increased numbers of swollen or lysed mitochondria. This study provides additional evidence that, at this exposure level, in vitro cardiac muscle performance is irreversibly decreased and mitochondrial morphology is altered.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
