Abstract
Background: Solid pseudopapillary tumours (SPT) of pancreas is an unusual neoplasm with uncertain malignant potential. It is seen predominantly in adolescent girls and young women. We present the clinical, ultrasound-guided fine needle aspiration (US-FNA) cytologic features, differential diagnosis and immunohistochemical findings in SPT. Methods: A retrospective 4-year (2007–2010) fine needle aspiration samples of 8 solid pseudopapillary tumours of pancreas were reviewed. Results: The entire cases were cured with exploratory laparotomy. This study includes 8 cases (1 male, 7 female) of solid pseudopapillary tumours of pancreas. All these cases showed characteristic cytomorphological features displaying hypercellular smears with presence of several papillary fragments lined by multilayered anisomorphic atypical cells having fine chromatin with delicate nuclear groove, myxoid stroma and foamy macrophages in a haemorrhagic background. Conclusions: Correct preoperative cytological diagnosis of solid pseudopapillary tumours of pancreas may be accurately possible by US-FNA technique and also aids in treatment of the surgically curable cancer in the patients.
Highlights
Solid-pseudopapillary tumour of the pancreas (SPT) is a rare uncertain malignant potential tumour which has distinctive cytopathologic features
The tumours were solid in 3 patients (37.5%), mixed solid and cystic in 4 patients (50.0%), and cystic in 1 patients (12.5%)
A preoperative diagnosis of solid pseudopapillary tumour was made in 8 patients on the basis of ultrasound-guided fine needle aspiration (US-FNA) cytology
Summary
Solid-pseudopapillary tumour of the pancreas (SPT) is a rare uncertain malignant potential tumour which has distinctive cytopathologic features. It is known as “Frantz tumor” which was first described by Dr Frantz in 1959 [1]. SPT occurs more frequently in the body and tail of the pancreas of adolescent girls and young women This tumour can be large and can undergo degenerative cystic changes that are evidenced on clinical and radiographic studies [2]. Solid pseudopapillary tumours (SPT) of pancreas is an unusual neoplasm with uncertain malignant potential. It is seen predominantly in adolescent girls and young women. Ultrasound-guided fine needle aspiration (US-FNA) cytologic features, differential diagnosis and immunohistochemical findings in SPT
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