Clinical observation of pancreatoduodenectomy combined with Tegafur chemotherapy for solid pseudopapillary tumor of the pancreas

Abstract

Objective To investigate the clinical effect of pancreatoduodenectomy combined with Tegafur in the treatment of solid pseudopapillary tumor of the pancreas. Methods Retrospective analysis the cases of 84 patients with solid pseudopapillary tumor of the pancreas from Baoji People′s Hospital from January 2010 to January 2015. Among them, 34 patients received adjuvant chemotherapy such as fluorouracil before and after treatment (combined treatment group), and 50 cases were not treated with chemotherapy after operation surgical treatment group. The effective rate and control rate of patients with WHO solid tumors were compared and analyzed by Kaplan-Meier criteria. The survival rate of patients was calculated by the Karnofsky method, and the quality of life was compared and analyzed by using the score criteria. Measurement data were represented as ±s, and comparsion between groups was analyzed using the t test.Count data were evaluated by the percentage, and comparsion between groups was analyzed using the chi-square test. Results The effective rate and control rate of the combined treatment group were 85.29% and 97.06%, the surgical treatment group were 72.00% and 86.00%. The difference was statistically significant (P 0.05). After treatment, the level of Karnofsky score of two groups were significantly increased (P 0.05). The survival rate was 91.18% in the combined treatment group and 88% in the surgical treatment group, and the difference was statistically significant (P<0.05). Conclusion Solid pseudopapillary tumor of the pancreas in patients after pancreaticoduodenectomy combined with fluorouracil chemotherapy alone and surgery were compared, no significant difference in quality of life, but it can significantly improve the survival rate of patients. Key words: Pancreaticoduodenectomy; Antineoplastic combined chemotherapy protocols; Solid pseudopapillary tumor of pancreas; Tegafur; Survival rate