Ultrasound Scatterer Density Classification Using Convolutional Neural Networks and Patch Statistics.

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Quantitative ultrasound (QUS) can reveal crucial information on tissue properties, such as scatterer density. If the scatterer density per resolution cell is above or below 10, the tissue is considered as fully developed speckle (FDS) or underdeveloped speckle (UDS), respectively. Conventionally, the scatterer density has been classified using estimated statistical parameters of the amplitude of backscattered echoes. However, if the patch size is small, the estimation is not accurate. These parameters are also highly dependent on imaging settings. In this article, we adapt convolutional neural network (CNN) architectures for QUS and train them using simulation data. We further improve the network's performance by utilizing patch statistics as additional input channels. Inspired by deep supervision and multitask learning, we propose a second method to exploit patch statistics. We evaluate the networks using simulation data and experimental phantoms. We also compare our proposed methods with different classic and deep learning models and demonstrate their superior performance in the classification of tissues with different scatterer density values. The results also show that we are able to classify scatterer density in different imaging parameters with no need for a reference phantom. This work demonstrates the potential of CNNs in classifying scatterer density in ultrasound images.