Abstract
AbstractSpirooxindole derivatives have been efficiently synthesized via a three‐component reaction consisting of isatin, malononitrile/ pyrazole and various 1,3‐diketones using Fluorinated Graphene Oxide (FGO) as a green and metal free carbocatalyst, under sonication. The main advantages of this synthetic approach lie in its operational simplicity, easy catalyst recovery and recyclability, high yields and short reaction times. The prepared catalyst was characterized by various analytical techniques viz., UV‐Vis, FT‐IR Spectroscopy, TGA, TEM, FE‐SEM and EDX. The in vitro anthelmintic screening of synthesized compounds against a cestode, Raillietina sp. and a nematode parasite, Syphacia obvelata at 200 μg/mL and 800 μg/mL were also carried out which revealed a profound activity, with much reduced morality time of parasite. The SEM study indicated structure alterations in treated parasite, further validating the in vitro anthelmintic property. In addition, molecular docking studies were carried out against β‐tubulin protein to determine binding affinity of the synthesized compounds. All test compound followed the “Lipinski Rule of Five” and in silico pharmacokinetic investigation showed inhibitory activity against CYP enzyme and P‐glycoprotein which may further improve the bio efficacy of compounds.
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