Abstract
The strength of molecular interaction between thyroxine hormone (THY) and two widely used anti-tuberculosis (ATB) drugs, ethambutol(ETH) and rifampicin(RIF) is assessed through ultrasonic at various blend compositions of the hormone and drugs. Ultrasonic study is carried out at three different temperatures (303 K, 310 K and 313 K). The trend in acoustical properties with blend ratio is used to establish the molecular interaction between thyroxine and ATB drugs. The main aim of this study is to identify the blend ratios and the temperature at which the hormone-drug interaction is significant in aqueous medium. DFT analysis is carried out to understand the type of interaction. The results obtained in DFT analysis of the complexes of thyroxine and drug molecules support the experimental observations. Both studies suggest that THY-RIF interaction is stronger than ETH-THY interaction.
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