Ultrasonic assisted structures and biological characteristics of nanoscale silver coordination polymers with cyanide, azide and 4,4\\-bipyridine ligands

Abstract

Ultrasonic self-assembly method was utilized to prepare new nano supramolecular coordination polymers (SCPs), 3∞[AgN3(bpy)], NSCP1 and 3∞[(AgCN)2 (bpy)], NSCP2 [bpy= 4,4\\-bipyridine] while the single crystals were prepared at ambient conditions. The silver atom in 1 acquires square planer geometry via coordination to four nitrogen atoms while NSCP2 contains two crystallographically different silver atoms adopting distorted trigonal planar geometry. The structures extend via corrugated catenated (AgN3) or (AgCN) chains which are linked by bpy forming 2D-layer structure. The 2D-layers are interconnected by π–π stacking, H- bonds and argentophilic interactions creating 3D-network structure. TEM images support nanoscale particles of NSCPs1 and 2. NSCPs 1 and 2 had been utilized as potent anticancer and anti-pathogenic micro-organisms. In vitro cytotoxicity and cell viable activity of the NSCPs1 and 2 had been studied against a set of different human cancer cell lines. The higher level of the NSCPs cytotoxicity was recorded against MCF-7 and HePG2 cells. Also, they own a good ability to inhibit the growth of the tested neoplastic cells and a poor effect on the normal cells in comparison with the results of cisplatin. Also, antioxidant activities, erythrocyte hemolysis, DNA binding and antimicrobial activities had been investigated.