Structure and characterization of organotin bimetallic supramolecular coordination polymers based on copper cyanide building blocks and pyrazine or pyrazine‐2‐carboxylic acid as new promising anticancer agents

Abstract

The supramolecular coordination polymers (SCP);∞3[Cu (CN)2(Me3Sn)(pyz)], pyrazine‐trimethyltin‐bis (cyanide) copperISCP1, [Cu2(CN)3(Ph3Sn)(pyz)], pyrazine‐triphenyltin‐tris (cyanide) dicopperISCP3and [Cu2(CN)4(Ph3Sn)(Pyz2caH)2], bis‐pyrazine‐2‐carboxylic acid‐ triphenyltin‐tetrakis (cyanide) dicopperISCP4and the coordination complex (CC), [CuII(Pyz2‐ca)2(H2O)2]; diaquo‐bis‐(pyrazine‐2‐carboxylato) copper(II)complex: CC2, are synthesized by self‐assembly method at ambient conditions. Single crystal X‐ray structures of SCP1and CC2indicate the presence of CuIand CuIIwhich adopt tetrahedral and octahedron geometry, respectively. The structures of SCP3and SCP4are solved by the density functional theory (DFT) calculations and spectroscopic methods. The Cu centers acquire triagonal plane, linear and tetrahedral geometry, respectively. The CN‐R3Sn‐NC spacer and pyrazine or pyrazine‐2‐carboxylic acid ligands extend the structures to 3D‐network. The tested compounds1–4are designed and synthesized to examine their effects on viability and proliferation of five human cancer cell lines. Also, they are tested for antioxidant activity using ABTS assay and rate erythrocyte hemolysis.