Abstract
Core–shell particles (CSPs), also known as superficially porous particles or fused-core particles, consisting of a solid core and a porous shell, have emerged as an advanced technology in high-performance liquid chromatography (HPLC). We report here an ultrasonic-assisted sol–gel method for the fabrication of CSPs with uniform mesoporous silica shell using tetraethoxysilane as the silica source and dodecylamine as a catalyst, template and porogen agent in a methanol–water solution. Instead of stirring, sonication was adopted to guarantee the particles monodispersity and uniformity. The shell thickness between 300 and 700 nm could be obtained by adjusting the sonication time and the volume ratio of methanol–water. Pore sizes from 3.4 to 8.5 nm were tuned by hydrothermal treatment. The C18-bonded 2.7 μm CSPs with a shell thickness of ~ 500 nm showed some advantages over a commercial 1.7 μm BEH column, and successfully applied for the analyses of a Chinese medicine and peptides. The CSPs could be a promising candidate as HPLC packing materials.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
More From: Journal of Inorganic and Organometallic Polymers and Materials
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.