Abstract

A new synthetic method leading to the formation of polycaprolactone (PCL)/iron oxide nanoparticles using polyvinylpyrrolidone (PVP) is described. The unique feature of this method is that the conventional polymerization step can be avoided. A stable colloidal dispersion of the PCL-coated iron oxide nanoparticles (PCLNP) is thus formed in the presence of PVP as a stabilizer. The PCLNP has a mean diameter of 20–50 nm as measured by TEM. Magnetic measurement by SQUID shows that the PCLNP has a strong superparamagnetism to be used as a liver MR T2 agent.

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